Qhia PQQ: Qhov Kawg Zog Booster rau Lub Siab thiab Lub Cev

Qhia PQQ: Qhov Kawg Zog Booster rau Lub Siab thiab Lub Cev

Pyrroloquinoline quinone, hu ua PQQ, yog ib pawg tshiab prosthetic nrog cov haujlwm zoo sib xws rau cov vitamins. Nws yog dav pom nyob rau hauv prokaryotes, nroj tsuag thiab tsiaj txhu, xws li fermented soybeans los yog natto, ntsuab peppers, kiwi txiv hmab txiv ntoo, Parsley, tshuaj yej, papaya, spinach, celery, mis nyuj, thiab lwm yam.

Nyob rau hauv xyoo tas los no, PQQ tau dhau los ua ib qho ntawm "lub hnub qub" cov khoom noj uas tau nyiam cov neeg nyiam. Hauv 2022 thiab 2023, kuv lub teb chaws tau pom zoo PQQ tsim los ntawm kev sib txuas thiab fermentation ua cov khoom noj tshiab.

Kev ua haujlwm lom neeg ntawm PQQ feem ntau yog tsom rau ob yam. Ua ntej, nws tuaj yeem txhawb kev loj hlob thiab kev loj hlob ntawm mitochondria thiab txhawb kev loj hlob sai ntawm tib neeg lub hlwb; thib ob, nws muaj cov khoom zoo antioxidant, uas tuaj yeem pab tshem tawm cov dawb radicals thiab txo cov cell puas. Ob txoj haujlwm no ua rau nws ua lub luag haujlwm muaj zog hauv lub hlwb kev noj qab haus huv, kev noj qab haus huv ntawm lub plawv, kev noj qab haus huv metabolic thiab lwm yam. Vim tias tib neeg lub cev tsis tuaj yeem tsim cov PQQ ntawm nws tus kheej, nws yuav tsum tau ntxiv los ntawm kev noj zaub mov.

01.PQQ lub luag haujlwm hauv kev txhim kho kev txawj ntse yog tshwj xeeb muaj nuj nqis

Thaum Lub Ob Hlis 2023, cov kws tshawb fawb Nyij Pooj tau luam tawm cov ntawv tshawb fawb hu ua "Pyrroloquinoline quinone disodium ntsev txhim kho lub hlwb ua haujlwm hauv cov neeg laus thiab cov laus" hauv phau ntawv xov xwm "Food & Function", qhia txog kev paub txog PQQ rau cov hluas thiab cov laus hauv Nyij Pooj. Kev tshawb fawb tau zoo dua.

Txoj kev tshawb no yog ob qhov muag tsis pom kev placebo randomized tswj kev sim uas suav nrog 62 tus txiv neej noj qab haus huv Nyij Pooj hnub nyoog 20-65 xyoo, nrog Mini-Mental State Scale cov qhab nia ≥ 24, uas tswj hwm lawv txoj kev ua neej qub thaum lub sijhawm kawm. Poj niam pawg. Cov kev tshawb fawb tau muab faib ua ib pawg kev cuam tshuam thiab pab pawg tswj hwm cov placebo, thiab tau txais qhov ncauj PQQ (20 mg / d) lossis placebo capsules txhua hnub rau 12 lub lis piam. Ib qho kev sim online uas tsim los ntawm lub tuam txhab tau siv los txheeb xyuas lub lis piam 0/8/12. Kev ntsuam xyuas kev txawj ntse ntsuas 15 lub hlwb hauv qab no.

Cov txiaj ntsig tau pom tias piv nrog pab pawg tswj hwm cov placebo, tom qab 12 lub lis piam ntawm kev noj PQQ, cov qhab nia sib xyaw thiab kev hais lus ntawm txhua pab pawg thiab cov neeg laus tau nce; Tom qab 8 lub lis piam ntawm kev noj PQQ, cov tub ntxhais hluas cov kev paub yooj yim, kev ua haujlwm nrawm thiab Kev Ua Haujlwm nrawm tau nce.

02 PQQ tsis tuaj yeem txhim kho lub hlwb ua haujlwm ntawm cov neeg laus, tab sis kuj txhim kho lub hlwb cov lus teb ntawm cov tub ntxhais hluas!

Thaum Lub Peb Hlis 2023, cov ntawv xov xwm thoob ntiaj teb muaj npe nrov hauv Food & Function tau luam tawm cov ntawv tshawb fawb hu ua "Pyrroloquinoline quinone disodium ntsev txhim kho lub hlwb ua haujlwm rau cov laus thiab cov laus". Txoj kev tshawb no tau tshawb xyuas qhov cuam tshuam ntawm PQQ ntawm kev paub txog kev ua haujlwm ntawm cov neeg laus hnub nyoog 20-65, nthuav dav cov pej xeem ntawm PQQ los ntawm cov neeg laus mus rau cov hluas. Txoj kev tshawb no tau ua pov thawj tias PQQ tuaj yeem txhim kho kev txawj ntse ntawm cov neeg ntawm txhua lub hnub nyoog.

Kev tshawb fawb tau pom tias PQQ, raws li cov khoom noj muaj txiaj ntsig, tuaj yeem txhim kho lub hlwb ua haujlwm txhua lub hnub nyoog, thiab xav kom nthuav dav siv PQQ ua zaub mov ua haujlwm los ntawm cov neeg laus rau cov neeg ntawm txhua lub hnub nyoog.

03 PQQ ua tus activator ntawm "cell zog factories" los kho lawv cov kev noj qab haus huv

Nyob rau lub Tsib Hlis 2023, Cell Death Dis tau luam tawm ib daim ntawv tshawb fawb txog kev rog rog ua rau cov kab mob cardiolipin-dependent mitophagy thiab kev kho mob intercellular mitochondrial hloov peev xwm ntawm mesenchymal qia hlwb. Txoj kev tshawb no tshawb pom PQQ los ntawm kev tshuaj xyuas seb puas muaj peev xwm ntawm intercellular mitochondrial pub muaj peev xwm ntawm cov neeg rog rog (cov neeg uas muaj cov kab mob metabolic) thiab kev kho mob ntawm cov kab mob mesenchymal qia hlwb (MSCs) puas, thiab seb puas muaj kev kho mob mitochondrial tuaj yeem thim rov qab. Modulation restores mitochondrial kev noj qab haus huv los txo cov kev puas tsuaj mitophagy.
Txoj kev tshawb no muab thawj qhov kev nkag siab ntawm molecular kev nkag siab ntawm impaired mitophagy nyob rau hauv rog-derived mesenchymal qia hlwb thiab qhia tau hais tias mitochondrial kev noj qab haus huv tuaj yeem rov qab los ntawm PQQ txoj cai los txo qis mitophagy.

04 PQQ tuaj yeem txhim kho tib neeg metabolic muaj nuj nqi

Thaum lub Tsib Hlis 2023, ib tsab xov xwm tshuaj xyuas hu ua "Pyrroloquinoline-quinone los txo cov rog thiab txo cov rog rog" tau luam tawm nyob rau hauv phau ntawv journal Front Mol Biosci, uas tau sau tseg 5 kev tshawb fawb tsiaj thiab 2 kev tshawb fawb ntawm tes.
Cov txiaj ntsig tau pom tias PQQ tuaj yeem txo cov rog hauv lub cev, tshwj xeeb tshaj yog visceral thiab daim siab rog ntau ntxiv, yog li tiv thaiv kev rog rog. Los ntawm kev tsom xam, PQQ feem ntau inhibits lipogenesis thiab txo cov rog los ntawm kev txhim kho mitochondrial muaj nuj nqi thiab txhawb lipid metabolism.

05 PQQ tuaj yeem tiv thaiv osteoporosis los ntawm ntuj laus

Thaum lub Cuaj Hlis 2023, Aging Cell tau luam tawm cov ntawv tshawb fawb hu ua "Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a new MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation" online. Txoj kev tshawb no, los ntawm kev sim ntawm cov nas, pom tau tias kev noj zaub mov PQQ tuaj yeem tiv thaiv pob txha los ntawm kev laus. Lub hauv paus txheej txheem ntawm PQQ lub zog antioxidant muaj peev xwm muab kev sim hauv paus rau PQQ kev siv los ua kev noj haus ntxiv rau kev tiv thaiv cov hnub nyoog ntsig txog osteoporosis.
Txoj kev tshawb no nthuav tawm lub luag haujlwm zoo thiab cov txheej txheem tshiab ntawm PQQ hauv kev tiv thaiv thiab kho cov pob txha pob txha senile, thiab ua pov thawj tias PQQ yuav raug siv los ua kev noj zaub mov zoo thiab muaj txiaj ntsig zoo los tiv thaiv thiab kho tus neeg laus pob txha. Nyob rau tib lub sijhawm, nws tau tshaj tawm tias PQQ ua rau MCM3-Keap1-Nrf2 teeb liab hauv osteoblasts, transcriptionally upregulates kev qhia ntawm antioxidant noob thiab Fbn1 noob, inhibits oxidative kev nyuaj siab thiab osteoclast pob txha resorption, thiab txhawb osteoblast pob txha tsim, yog li tiv thaiv kev laus. lub luag haujlwm hauv qhov tshwm sim ntawm kev sib deev osteoporosis.

06 Ntxiv PQQ tuaj yeem tiv thaiv cov hlwb pob txha caj qaum thiab txhim kho qhov muag!

Thaum lub Cuaj Hlis 2023, phau ntawv xov xwm Acta Neuropathol Commun tau luam tawm ib qho kev tshawb fawb los ntawm cov kws paub txog ophthalmology thiab kws tshawb fawb los ntawm Lub Tsev Kho Mob Qhov Muag ntawm Karolinska Institutet hauv Stockholm, Sweden, lub tsev kawm kho mob nto moo European, nrog rau Royal Victoria Qhov Muag thiab Pob Ntseg Tsev Kho Mob hauv Australia, thiab Department of Biology ntawm University of Pisa hauv Ltalis. Nws yog lub npe hu ua "Pyrroloquinoline quinone drives ATP synthesis hauv vitro thiab hauv vivo thiab muab retinal ganglion cell neuroprotection." Kev tshawb fawb tau ua pov thawj tias PQQ muaj kev tiv thaiv ntawm cov kab mob qog nqaij hlav retinal ganglion (RGC) thiab muaj peev xwm ua tau zoo li tus neeg saib xyuas neuroprotective tshiab hauv kev tawm tsam retinal ganglion cell apoptosis.
Cov kev tshawb pom txhawb nqa lub luag haujlwm ntawm PQQ ua tus neeg sawv cev tshiab pom cov neuroprotective uas tuaj yeem txhim kho qhov ua haujlwm ntawm cov hlwb hauv lub hlwb thaum txo qis kev pheej hmoo ntawm cov kev mob tshwm sim. Tib lub sijhawm, cov kws tshawb fawb ntseeg tias kev ntxiv PQQ yog ib qho kev xaiv zoo rau kev saib xyuas qhov muag.

07 Ntxiv PQQ tuaj yeem tswj cov hnyuv, txhim kho cov thyroid ua haujlwm, thiab txo cov thyroid puas.

Thaum Lub Kaum Ob Hlis 2023, pab pawg tshawb fawb los ntawm Shanghai Tenth People's Hospital ntawm Tongji University School of Medicine tau luam tawm ib tsab xov xwm hu ua "Lub Luag Haujlwm Muaj Peev Xwm ntawm Pyrroloquinoline Quinone los Tswj Cov Thyroid Function thiab Gut Microbiota Composition of Graves' Disease in Mice" nyob rau hauv phau ntawv xov xwm Pol J Microbiol Hauv tsab xov xwm no, cov kws tshawb fawb tuaj yeem siv cov tshuaj ntxiv rau Q. flora, alleviate plab hnyuv puas, thiab txhim kho cov thyroid ua haujlwm.
Txoj kev tshawb nrhiav pom qhov cuam tshuam ntawm PQQ supplementation ntawm GD nas thiab lawv cov hnyuv:

01 Tom qab PQQ supplementation, cov ntshav TSHR thiab T4 ntawm GD nas raug txo, thiab qhov loj ntawm cov thyroid caj pas tau txo qis.

02 PQQ txo qhov mob thiab oxidative kev nyuaj siab, thiab txo cov hnyuv me me epithelial puas.

03 PQQ muaj cov txiaj ntsig tseem ceeb ntawm kev rov ua kom muaj ntau haiv neeg thiab muaj pes tsawg leeg ntawm microbiota.

04 Piv nrog rau pawg GD, PQQ kev kho mob tuaj yeem txo qis Lactobacilli ntau hauv cov nas (qhov no yog lub hom phiaj kho mob rau cov txheej txheem GD).

Hauv cov ntsiab lus, PQQ supplementation tuaj yeem tswj cov thyroid muaj nuj nqi, txo cov thyroid puas, thiab txo qhov mob thiab oxidative kev nyuaj siab, li no alleviating me me plab hnyuv epithelial puas. Thiab PQQ kuj tuaj yeem kho qhov sib txawv ntawm cov hnyuv.

Ntxiv nrog rau cov kev tshawb fawb saum toj no ua pov thawj lub luag haujlwm tseem ceeb thiab tsis muaj peev xwm ntawm PQQ raws li kev noj haus ntxiv los txhim kho tib neeg kev noj qab haus huv, cov kev tshawb fawb yav dhau los tseem tau txuas ntxiv kom paub meej cov haujlwm muaj zog ntawm PQQ.

08 PQQ tuaj yeem txhim kho pulmonary hypertension

Thaum Lub Kaum Hli 2022, cov ntawv tshawb fawb hu ua "Pyrroloquinoline quinone (PQQ) txhim kho pulmonary hypertension los ntawm kev tswj cov mitochondrial thiab metabolic functions" tau luam tawm nyob rau hauv phau ntawv journal Pulmonary Pharmacology & Therapeutics, aiming los tshawb txog lub luag hauj lwm ntawm PQQ hauv kev txhim kho pulmonary hypertension.
Cov txiaj ntsig tau pom tias PQQ tuaj yeem txo qis mitochondrial abnormalities thiab metabolic abnormalities nyob rau hauv pulmonary artery smooth nqaij hlwb thiab ncua kev loj hlob ntawm pulmonary hypertension nyob rau hauv nas; Yog li ntawd, PQQ tuaj yeem siv los ua tus neeg sawv cev kho mob los txhim kho pulmonary hypertension.

09 PQQ tuaj yeem ncua kev laus ntawm tes thiab txuas lub neej!

Thaum Lub Ib Hlis 2020, cov ntawv tshawb fawb hu ua Pyrroloquinoline quinone ncua kev mob tshwm sim los ntawm TNF-α los ntawm p16/p21 thiab Jagged1 cov kev taw qhia txoj hauv kev luam tawm hauv Clin Exp Pharmacol Physiol ncaj qha txheeb xyuas qhov kev tiv thaiv kev laus ntawm PQQ hauv tib neeg lub hlwb. , cov txiaj ntsig tau pom tias PQQ ncua kev laus ntawm tib neeg lub cev thiab tuaj yeem ua rau lub neej ntev.

Cov kws tshawb fawb tau pom tias PQQ tuaj yeem ncua sijhawm tib neeg lub cell aging, thiab tshawb xyuas qhov kev txiav txim siab ntxiv los ntawm kev qhia cov txiaj ntsig ntawm ntau yam biomarkers xws li p21, p16, thiab Jagged1. Nws tau pom tias PQQ tuaj yeem txhim kho kev noj qab haus huv tag nrho ntawm cov pej xeem thiab txuas ntxiv lub neej ntev.

10 PQQ tuaj yeem tiv thaiv kev laus ntawm zes qe menyuam thiab tswj fertility

Nyob rau lub Peb Hlis 2022, ib daim ntawv tshawb fawb hu ua "PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice" tau luam tawm nyob rau hauv phau ntawv Journal Front Endocrinol, aiming los kawm seb PQQ noj cov tshuaj tiv thaiv alkylating tus neeg saib xyuas-induced zes qe menyuam dysfunction. nyhuv.
Cov txiaj ntsig tau pom tias PQQ supplementation nce qhov hnyav thiab qhov loj ntawm lub zes qe menyuam, ib nrab rov qab los ntawm lub voj voog estrous, thiab tiv thaiv kev poob ntawm cov follicles hauv nas kho nrog cov tshuaj alkylating. Tsis tas li ntawd, PQQ supplementation ho nce cev xeeb tub tus nqi thiab litter loj ib tug me nyuam nyob rau hauv alkylating tus neeg saib xyuas-kho nas. Cov txiaj ntsig no qhia txog qhov muaj peev xwm cuam tshuam ntawm PQQ supplementation hauv alkylating tus neeg saib xyuas-induced zes qe menyuam tsis ua haujlwm.

Xaus
Qhov tseeb, raws li kev noj zaub mov tshiab, PQQ tau lees paub rau nws cov txiaj ntsig zoo ntawm kev noj haus thiab kev noj qab haus huv. Vim nws txoj haujlwm muaj zog, kev nyab xeeb siab thiab kev ruaj ntseg zoo, nws muaj qhov kev loj hlob dav dav hauv cov khoom noj khoom haus.
Nyob rau hauv xyoo tas los no, nrog rau kev nkag siab ntawm kev paub, PQQ tau ua tiav cov ntawv pov thawj kev ua tau zoo tshaj plaws thiab tau dav siv los ua cov khoom noj khoom haus lossis khoom noj hauv Tebchaws Meskas, Tebchaws Europe thiab lwm lub tebchaws thiab cheeb tsam. Raws li cov neeg siv khoom hauv tsev paub txog txuas ntxiv mus ntxiv, nws ntseeg tias PQQ, ua cov khoom noj tshiab, yuav tsim lub ntiaj teb tshiab hauv kev lag luam hauv tsev.

Cov ntaub ntawv:

1.TAMAKOSHI M, SUZUKI T, NISHIHARA E, et al. Pyrroloquinoline quinone disodium ntsev txhim kho lub hlwb ua haujlwm hauv cov neeg laus thiab cov laus [J]. Food & Function, 2023, 14(5): 2496-501.doi: 10.1039/d2fo01515c.2. Masanori Tamakoshi, Tomomi Suzuki, Eiichiro Nishahara, thiab al. Pyrroloquinoline quinone disodium ntsev txhim kho lub hlwb ua haujlwm hauv cov neeg laus thiab cov laus. Randomized Controlled Trial Food Funct. 2023 Mar 6; 14(5): 2496-2501. PIB: 36807425.3. Shakti Sagar, Md Imam Faizan, Nisha Chaudhary, et al. Obesity impairs cardiolipin-dependent mitophagy thiab kho intercellular mitochondrial hloov peev xwm ntawm mesenchymal qia hlwb. Cell Tuag Dis. 2023 Peb 13; 14(5):324. doi: 10.1038/s41419-023-05810-3 ib. PIB: 37173333.4. Nur Syafiqah Mohamad Ishak, Kazuto Ikemoto. Pyrroloquinoline-quinone los txo cov rog thiab txo cov rog rog. FrontMolBiosci.2023May 5:10:1200025. doi: 10.3389/fmolb.2023.1200025. PMID: 37214340.5.Jie Li, Jing Zhang, Qi Xue, et al. Pyrroloquinoline quinone alleviates natural aging-related osteoporosis ntawm ib qho tshiab MCM3-Keap1-Nrf2 axis-mediated stress response thiab Fbn1 upregulation. Kev laus Cell. 2023 Sep; 22(9):e13912. doi: 10.1111/acel.13912 ib. Epub 2023 Jun 26. PMID: 37365714.6. Alessio Canovai, James R Tribble, Melissa Jöe. thiab. al. Pyrroloquinoline quinone tsav ATP synthesis nyob rau hauv vitro thiab hauv vivo thiab muab kev tiv thaiv kab mob qog nqaij hlav hauv hlwb. Acta Neuropathol Sib Tham. 2023 Sep 8; 11(1): 146. doi: 10.1186/s40478-023-01642-6 ib. PIB: 37684640.7. Xiaoyan Liu, Wen Jiang, Ganghua Lu, et al. Lub luag haujlwm muaj peev xwm ntawm Pyrroloquinoline Quinone los tswj cov thyroid muaj nuj nqi thiab plab microbiota muaj pes tsawg leeg ntawm Graves' Kab Mob hauv nas. Pol J Microbiol. 2023 Dec 16; 72(4): 443-460. doi: 10.33073/pjm-2023-042. eCollection 2023 Dec 1. PMID: 38095308.8. Shafiq, Mohammad et al. "Pyrroloquinoline quinone (PQQ) txhim kho pulmonary hypertension los ntawm kev tswj cov mitochondrial thiab metabolic zog." Pulmonary Pharmaology & Therapeutics Vol. 76 (2022): 102156. doi: 10.1016/j.pupt.2022.1021569. Ying Gao, Teru Kamogashira, Chisato Fujimoto. ua al. Pyrroloquinoline quinone ncua kev mob tshwm sim los ntawm TNF-α los ntawm p16 / p21 thiab Jagged1 txoj kev taw qhia. Clin Exp Pharmacol Physiol. 2020 Jan; 47(1):102-110. doi: 10.1111/1440-1681.13176 ib. PMID: 31520547.10.Dai, Xiuliang et al. "PQQ Kev Noj Qab Haus Huv Ntxiv Tiv Thaiv Alkylating Agent-Induced Ovarian Dysfunction nyob rau hauv nas." Frontiers hauv endocrinology vol. 13 781404. 7 Peb. 2022, doi: 10.3389/fendo.2022.781404