Cov khoom
Dej-Soluble Quercetin rau Superior Nutrient Delivery
Dej-Soluble Quercetin: Txhim kho Bioavailability thiab Pioneering Lub Sij Hawm Tshiab ntawm Kev Noj Qab Haus Huv
Quercetin, flavonoid compound muaj ntau pom nyob rau hauv ntau yam khoom noj xws li dos, txiv apples, thiab txiv hmab txiv ntoo, tau ntev ua lub ntsiab lus tseem ceeb hauv kev tshawb fawb thiab kev sib tham txog kev noj qab haus huv, ua tsaug rau nws cov muaj zog antioxidant, tiv thaiv kab mob, thiab lwm yam kev ua si lom neeg. Txawm li cas los xij, nws qhov tsis zoo ntawm cov dej solubility tseem ceeb cuam tshuam nws txoj kev nqus thiab kev siv hauv tib neeg lub cev, yog li txwv kev ua tiav tag nrho ntawm nws cov txiaj ntsig kev noj qab haus huv. Nyob rau hauv xyoo tas los no, nrog kev nce qib hauv kev tshawb fawb thiab thev naus laus zis, cov dej-soluble quercetin tau tshwm sim, kov yeej cov kev sib tw solubility ntawm cov tshuaj quercetin thiab nthuav tawm cov kev siv dav dav thiab cov txiaj ntsig tshwj xeeb.
Revolutionizing Bioavailability: Overcoming Absorption Barriers
Ib txwm quercetin, vim nws cov dej solubility tsawg, tawm tsam kom yaj hauv plab hnyuv tom qab kev tswj hwm qhov ncauj, ua rau muaj qhov nqus tsawg heev. Kev tshawb fawb qhia tau tias nws txoj hnyuv nqus tau tsuas yog nyob ib ncig ntawm 2%. Nyob rau hauv sib piv, dej-soluble quercetin leverages tej-edge technologies, xws li nanomicelle technology thiab cyclodextrin inclusion technology, dramatically txhim kho nws solubility nyob rau hauv dej. Piv txwv li, Dryland New Materials Laboratory ntawm South Subtropical Crops Research Institute, Suav Academy ntawm Tropical Agricultural Sciences, tau ua tiav kev npaj quercetin-loaded nanomicelles los ntawm kev sib txuas tshuaj. Qhov kev tsim kho tshiab no tau txhim kho quercetin cov dej solubility, photostability, thiab cellular uptake efficiency. Raws li qhov tshwm sim, quercetin tuaj yeem yaj tau yooj yim dua hauv cov kua dej hauv plab, ua rau nws qhov chaw sib cuag nrog cov hnyuv mucosal thiab txhawb nws txoj kev nqus zoo hauv tib neeg lub cev. Cov kev tshawb fawb ntsig txog pom tau tias bioavailability ntawm dej-soluble quercetin tuaj yeem nce ntxiv los ntawm ob peb zaug lossis ntau dua piv rau cov tshuaj quercetin, ua rau lub cev nqus tau zoo dua thiab siv cov khoom nquag ntawm quercetin thiab tag nrho nws cov txiaj ntsig kev noj qab haus huv.
Daim ntawv thov kev noj qab haus huv ntau yam
1. Kev tswj ntshav qabzib
Cov dej-soluble quercetin muaj kev cia siab tshiab rau cov tib neeg txhawj xeeb txog kev noj qab haus huv ntawm cov ntshav qabzib. Kev tshawb fawb los ntawm Zhengzhou Fruit Research Institute, Suav Academy ntawm Kev Tshawb Fawb Txog Kev Ua Liaj Ua Teb, tau qhia tias quercetin, ua ke nrog lwm cov txiv hmab txiv ntoo flavonoids, tuaj yeem cuam tshuam kev ua haujlwm ntawm α-glucosidase. α-Glucosidase plays lub luag haujlwm tseem ceeb hauv hydrolysis ntawm carbohydrates, thiab inhibiting nws cov haujlwm tuaj yeem thaiv kev zom zaub mov thiab nqus cov carbohydrates, yog li pab tswj cov ntshav qabzib tom qab. Nrog nws cov solubility zoo heev thiab absorbability, dej-soluble quercetin tuaj yeem koom nrog inhibition ntawm α-glucosidase, muab kev txhawb nqa zoo rau kev txhim kho cov khoom siv ua haujlwm txhawm rau tswj cov ntshav qabzib tom qab. Qhov no muaj qhov cuam tshuam tseem ceeb rau kev tswj hwm kev noj qab haus huv niaj hnub ntawm cov neeg mob ntshav qab zib lossis cov neeg muaj ntshav qabzib hloov pauv.
2. Kev tiv thaiv kab mob siab
Cov dej-soluble quercetin kuj ci hauv kev tswj lub siab noj qab haus huv. Ib txoj kev tshawb fawb los ntawm xibfwb Peng Cheng pab neeg los ntawm Chengdu University of Traditional suav tshuaj tau pom tias quercetin tuaj yeem ua kom lub siab ua kua dej cawv los ntawm kev sib haum xeeb ntawm kev hloov pauv nuclear ntawm TFEB los them rau qhov tsis txaus autophagy. Kev txhim kho absorbability ntawm dej-soluble quercetin tso cai rau nws mus cuag lub siab sai thiab zoo, ntxiv dag zog rau lub autophagic muaj nuj nqi ntawm daim siab hlwb, txhawb lub metabolism ntawm cov rog nyob rau hauv lub siab, thiab pab tshem tawm cov teeb meem tshuaj. Qhov no pab tiv thaiv thiab txhim kho ntau yam kab mob siab, xws li daim siab rog thiab kab mob siab cawv, los ntawm kev txo qis kev puas tsuaj los ntawm cawv thiab lwm yam rau lub siab.
3. Cov plaub hau Regeneration Promotion
Cov plaub hau poob yog ib qho kev txhawj xeeb rau ntau tus neeg, thiab dej-soluble quercetin muab cov kev daws teeb meem tshiab rau qhov teeb meem no. Kev koom tes kev tshawb fawb los ntawm xib fwb Qu Jing pab neeg los ntawm lub koom haum ntawm Zoology, Suav Academy ntawm Sciences, tau pom tias quercetin tuaj yeem txhawb cov plaub hau regrowth zoo los ntawm kev ua kom HIF-1 txoj hauv kev hauv endothelial hlwb ntawm cov plaub hau follicle microenvironment. Cov dej-soluble quercetin tuaj yeem nkag mus rau hauv cov hlab ntsha ntau dua thiab ncav cuag thaj tsam ntawm cov hauv paus plaub hau, ua tiav nws cov kev tswj hwm ntawm cov plaub hau follicle microenvironment. Nws txhawb kev sib txawv thiab kev loj hlob ntawm cov plaub hau follicle qia hlwb, yog li txhawb cov plaub hau kev loj hlob. Txawm hais tias cov plaub hau poob yog tshwm sim los ntawm kev ntxhov siab, hormonal imbalances, los yog lwm yam, dej-soluble quercetin tuav cov lus cog tseg raws li kev kho kom zoo thiab muaj txiaj ntsig zoo.
4. Kev tiv thaiv kab mob
Quercetin nws tus kheej muaj qee yam kev ua haujlwm immunomodulatory, xws li txhawb kev ua kom macrophage thiab tso tawm ntawm cov kab mob tiv thaiv kab mob. Lub advent ntawm dej-soluble quercetin ntxiv amplifates cov zoo. Nws cov dej solubility zoo heev ua kom muaj kev sib faib ntau dua hauv lub cev, ua kom nws ua tau zoo dua rau ntau yam ntawm lub cev tiv thaiv kab mob. Nws txhim kho kev ua haujlwm ntawm lub cev tiv thaiv kab mob thiab txhawb kev tso tawm ntawm kev tiv thaiv kab mob xws li qog necrosis factor-α thiab interferon-γ, pab lub cev zoo tiv thaiv cov kab mob sab nraud thiab txhawb kev tiv thaiv tag nrho. Qhov no tso cai rau cov tib neeg kom muaj zog tiv thaiv thaum ntsib teeb meem kev noj qab haus huv xws li kab mob khaub thuas thiab kab mob kab mob.
Kev nyab xeeb Profile thiab yav tom ntej Prospects
Kev npaj cov dej-soluble quercetin feem ntau siv kev nyab xeeb thiab eco-friendly technical le caag, xws li nanomicelle technology tau hais ua ntej. Cov txheej txheem no txhim kho quercetin cov dej solubility yam tsis muaj kev qhia txog cov tshuaj phem, ua kom cov khoom muaj kev nyab xeeb. Ntxiv mus, vim nws cov bioavailability zoo dua, qhov qis dua ntawm quercetin yuav tsum tau ua kom tiav cov txiaj ntsig kev noj qab haus huv tib yam, ntxiv kom txo qis qhov kev pheej hmoo ntawm qhov tshwm sim tsis zoo.
Nrog rau kev tshawb nrhiav txuas ntxiv mus thiab kev tsim kho tshiab ntawm cov thev naus laus zis, cov dej-soluble quercetin tau npaj los ua kom pom qhov muaj peev xwm ntau dua hauv cov khoom noj, tshuaj noj, tshuaj pleev ib ce, thiab kev lag luam tshuaj. Hauv thaj chaw ntawm cov khoom noj uas ua haujlwm, nws tuaj yeem muab tso rau hauv ntau yam dej haus thiab khoom noj txom ncauj, muab cov neeg siv kev tiv thaiv kev noj qab haus huv yooj yim. Hauv kev lag luam tshuaj pleev ib ce, leveraging nws cov plaub hau-regenerating thiab antioxidant zog, cov khoom uas muaj zog xws li tiv thaiv plaub hau poob thiab tiv thaiv daim tawv nqaij laus tuaj yeem tsim. Hauv kev lag luam tshuaj, muaj kev cog lus zoo rau kev tshawb nrhiav nws cov ntawv thov hauv kev kho cov kab mob ntev thiab pab kho cov tshuaj, qhib lub qab ntug tshiab rau kev tshawb fawb txog kev kho mob thiab kev noj qab haus huv yav tom ntej.
Cov ntaub ntawv
1.South Subtropical Crops Research Institute, Suav Academy ntawm Tropical Agricultural Sciences. (nd). Kev nce qib tshiab hauv Nano Sustained-Tshuaj Cov Khoom Siv Tshuaj. Tau txais los ntawm http://m.toutiao.com/group/7164215338974839308/?upstream_biz=doubao
2. Peng, C., et al. (nd). Quercetin alleviates ethanol - induced hepatic steatosis hauv L02 hlwb los ntawm activating TFEB translocation los them rau qhov tsis txaus autophagy. PHYTOTHERAPY RESEARCH (Second Category in Chinese Academy of Sciences). Tau txais los ntawm kev kawm databases
3.Qu, J., et al. (nd). Ib leeg - cell Profiling nthuav tawm lub luag haujlwm muaj peev xwm ntawm Quercetin hauv Kev Txhawb Cov Plaub Hau. Protein & Cell. Tau txais los ntawm https://m.thepaper.cn/newsDetail_forward_21318679
4.Jin, Z., et al. (2024). Co - encapsulation ntawm quercetin thiab resveratrol: Sib piv nyob rau hauv sib txawv txheej ntawm zein - carboxymethyl cellulose nanoparticles. International Journal of Biological Macromolecules, 263, Tshooj 127439. https://doi.org/10.1016/j.ijbiomac.2024.127439
5.Zhengzhou Fruit Research Institute, Suav Academy ntawm Agricultural Sciences. (2024). Flavonoids nyob rau hauv Txiv Hmab Txiv Ntoo Tswj Postprandial Ntshav Qab Zib. Tau txais los ntawm http://www.xinhuanet.com/science/20241105/c730eb7ee20a4e0ab8d2ec96570044ca/c.html
